Tiemonium Methylsulphate ( Spanium ) is an antispasmodic drug. It reduces the muscle spasm of the intestine, biliary system, bladder and uterus.
Pharmacology
Tiemonium Methylsulphate (Spanium ) rapidly relieves spasmodic condition through the inhibition of intracellular proteins by competitively antagonising acetylcholine and histamine and stabilizing the cell membrane by strengthening calcium binding with membrane phospholipids and proteins.
Spanium is indicated for the treatment of spasm of the intestine, biliary system, bladder and uterus
Tablet: The usual dose is 100 mg - 300 mg (2 to 6 tablets) per day in divided doses as required.
Injection: The usual dose is 5 mg (1 ampoule) by slow IM or IV injection 3 times per day
Overdosage
In over dosage, no data is available in case of Tiemonium Methylsulphate but there is a possibility of peripheral effects and other symptoms such as hyperthermia, hypertension, increased respiratory rate, nausea and vomiting may occur. A rash may appear on the face or upper trunk.
Tiemonium Methylsulphate may have some undesirable effects in certain individuals like- risk of hypotension & tachycardia, especially in case of injection.
Caution should be taken in cases of chronic bronchitis, coronary insufficiency, ambient hyperthermia, renal insufficiency and hepatic insufficiency.
The drug should not be used in glaucoma (acute pain of eyeball with vision disturbances), difficulty to urinate (disorders of prostate or bladder), tachycardia.
The use of this drug is not recommended during pregnancy or breast-feeding, unless indicated by physician.
The effects of Tiemonium Methysulphate may be enhanced by the concomitant use of other drugs with antimuscarinic properties such as amantadine, some antihistamines, phenothiazine, antipsychotics, and tricyclic antidepressants